About us

Our research team focuses on elucidating the role of intrinsically disordered proteins (IDPs) in biology. In particular, we are interested in the mitogen-activated protein kinase (MAPK) cell signaling pathways and how intrinsically disordered scaffold proteins regulate signaling specificity and MAPK activity. We use NMR spectroscopy combined with X-ray crystallography and biophysics to study these dynamic assemblies at atomic resolution.

Latest news

12/2024 Our new review on binding mechanisms of IDPs is out in Current Opinion in Structural Biology. Work led by former Ph.D. student and current postdoc Thibault Orand.

08/2024 Our new publication on the JIP1 and JIP2 scaffold proteins is out in Structure. We reveal the structural details of how the two scaffold proteins heterodimerize via their SH3 domains. Work led by postdocs Laura Mariño Pérez and Elise Delaforge in collaboration with the Palencia group.

03/2024 Stefan Nebl joins the team as an Impulscience postdoctoral fellow

11/2023 Marion Chenal joins the team as an Impulscience Ph.D. student

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