Our research team focuses on elucidating the role of intrinsically disordered proteins (IDPs) in biology. In particular, we are interested in the mitogen-activated protein kinase (MAPK) cell signaling pathways and how intrinsically disordered scaffold proteins regulate signaling specificity and MAPK activity. We use NMR spectroscopy combined with X-ray crystallography and biophysics to study these dynamic assemblies at atomic resolution.
07/2022 Join us! Several positions are now open to join our team.
07/2022 We are grateful to the Agence National de la Recherche (ANR) for funding an exciting project with the groups of Dr. Andres Palencia and Prof. Vincent Cattoir. We will be developing new drugs against pathogenic gram-positive bacteria to fight antibiotic resistance.
02/2022 How can aromatic residues undergo ring flipping in the core of a protein despite engaging in multiple stabilizing interactions to maintain protein fold? Read our new publication in Nature where we reveal the structural changes associated with ring flipping of a core tyrosine. Work led by postdoc Laura Mariño in collaboration with the Palencia group.
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