About us
Our research team focuses on elucidating the role of intrinsically disordered proteins (IDPs) in biology. In particular, we are interested in the mitogen-activated protein kinase (MAPK) cell signaling pathways and how intrinsically disordered scaffold proteins regulate signaling specificity and MAPK activity. We use NMR spectroscopy combined with X-ray crystallography and biophysics to study these dynamic assemblies at atomic resolution.
Latest news
02/2025 Our work on the intrinsically disordered scaffold protein JIP1 and its bipartite interaction with the kinase JNK1 is out in PNAS. Work led by postdocs Thibault Orand and Elise Delaforge in collaboration with the Palencia and Davis groups.
12/2024 Our review on binding mechanisms of IDPs is out in Current Opinion in Structural Biology. Work led by former Ph.D. student and current postdoc Thibault Orand.
08/2024 Our new publication on the JIP1 and JIP2 scaffold proteins is out in Structure. We reveal the structural details of how the two scaffold proteins heterodimerize via their SH3 domains. Work led by postdocs Laura Mariño Pérez and Elise Delaforge in collaboration with the Palencia group.
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